CMRR has 4 inter-related missions :
Clinical research
Drug trials, non-pharmacologic trials
📞 +33 4.92.03.47.78
📧 lemaire.j@chu-nice.fr
Cobtek team "Cognition Behaviour Technology"
Research on new technology, Information and Communication Technologies
➡️ Informations sur l'équipe Cobtek
Trainings for professionals (working in public and private practice).
CMRR main activity is the diagnosis and management of cognitive and memory disorders. CMRR has also an expertise in cognitive disturbances associated to Down syndrome, concussions in sport activities and rare neurodegenerative diseases.
Nowadays, memory and behavior disorders can be objectively assessed through clinical examination, neuropsychological tests, biological examinations and brain imaging.
These assessments often lead to the prescription of appropriate treatments.
Consultations may have several objectives :
Nice CMRR offers four types of consultations :
There are several Memory Centers around you where you may go for a memory consultation.
You can consult the list on the website of the Mederic Alzheimer Foundation ➡️ Consult the list
In order to help patients and carers, CMRR sets up different workshops :
Pharmacologic Approaches for the Management of Apathy in Neurodegenerative Disorders. Bogdan A, Manera V, Koenig A, David R. Front Pharmacol. 2020 Jan 23;10:1581. doi: 10.3389/fphar.2019.01581. eCollection 2019.
Absence of Relationship Between Self-Reported Sleep Measures and Amyloid Load in Elderly Subjects. Gabelle A, Gutierrez LA, Jaussent I, Ben Bouallegue F, De Verbizier D, Navucet S, Grasselli C, Bennys K, Marelli C, David R, Mariano-Goulart D, Andrieu S, Vellas B, Payoux P, Berr C, Dauvilliers Y.Front Neurol. 2019 Sep 13;10:989. doi: 10.3389/fneur.2019.00989. eCollection 2019.
Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort. Desmidt T, Delrieu J, Lebouvier T, Robert G, David R, Balageas AC, Surget A, Belzung C, Arlicot N, Ribeiro MJ, Payoux P, Vellas B, El-Hage W, Tavernier E, Camus V; MAPT/DSA study group. Neurobiol Aging. 2019 Aug 14;84:61-69. doi: 10.1016/j.neurobiolaging.2019.08.008.
Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders. Manera V, Abrahams S, Agüera-Ortiz L, Bremond F, David R, Fairchild K, Gros A, Hanon C, Husain M, König A, Lockwood PL, Pino M, Radakovic R, Robert G, Slachevsky A, Stella F, Tribouillard A, Trimarchi PD, Verhey F, Yesavage J, Zeghari R, Robert P. Am J Geriatr Psychiatry. 2019 Aug 9. pii: S1064-7481(19)30459-2. doi: 10.1016/j.jagp.2019.07.014
Relationships between objectives sleep parameters and brain amyloid load in subjects at risk to Alzheimer's disease: the INSIGHT-preAD Study. Ettore E, Bakardjian H, Solé M, Levy Nogueira M, Habert MO, Gabelle A, Dubois B, Robert P, David R. Sleep. 2019 Jul 2. pii: zsz137. doi: 10.1093/sleep/zsz137.
How many patients are eligible for disease-modifying treatment in Alzheimer's disease? A French national observational study over 5 years. Epelbaum S, Paquet C, Hugon J, Dumurgier J, Wallon D, Hannequin D, Jonveaux T, Besozzi A, Pouponneau S, Hommet C, Blanc F, Berly L, Julian A, Paccalin M, Pasquier F, Bellet J, Boutoleau-Bretonniere C, Charriau T, Rouaud O, Madec O, Mouton A, David R, Bekadar S, Fabre R, Liegey E, Deberdt W, Robert P, Dubois B. BMJ Open. 2019 Jun 24;9(6):e029663. doi: 10.1136/bmjopen-2019-029663.
Alzheimer's disease: Estimating its prevalence rate in a French geographical unit using the National Alzheimer Data Bank and national health insurance information systems. Bailly L, David R, Chevrier R, Grebet J, Moncada M, Fuch A, Sciortino V, Robert P, Pradier C. PLoS One. 2019 May 6;14(5):e0216221. doi: 10.1371/journal.pone.0216221.
Sex ratio in dementia with Lewy bodies balanced between Alzheimer's disease and Parkinson's disease dementia: a cross-sectional study. Mouton A, Blanc F, Gros A, Manera V, Fabre R, Sauleau E, Gomez-Luporsi I, Tifratene K, Friedman L, Thümmler S, Pradier C, Robert PH, David R. Alzheimers Res Ther. 2018 Sep 12;10(1):92. doi: 10.1186/s13195-018-0417-4.
Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group. Robert P, Lanctôt KL, Agüera-Ortiz L, Aalten P, Bremond F, Defrancesco M, Hanon C, David R, Dubois B, Dujardin K, Husain M, König A, Levy R, Mantua V, Meulien D, Miller D, Moebius HJ, Rasmussen J, Robert G, Ruthirakuhan M, Stella F, Yesavage J, Zeghari R, Manera V. Eur Psychiatry. 2018 Oct;54:71-76. doi: 10.1016/j.eurpsy.2018.07.008. Epub 2018 Aug 17.
Neural correlates of episodic memory in the Memento cohort. Epelbaum S, Bouteloup V, Mangin JF, La Corte V, Migliaccio R, Bertin H, Habert MO, Fischer C, Azouani C, Fillon L, Chupin M, Vellas B, Pasquier F, Dartigues JF, Blanc F, Gabelle A, Ceccaldi M, Krolak-Salmon P, Hugon J, Hanon O, Rouaud O, David R, Chêne G, Dubois B, Dufouil C. Alzheimers Dement (N Y). 2018 May 22;4:224-233. doi: 10.1016/j.trci.2018.03.010. eCollection 2018.
Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6. Thümmler S, Dor E, David R, Leali G, Battista M, David A, Askenazy F, Verstuyft C. Front Psychiatry. 2018 Jan 24;9:2. doi: 10.3389/fpsyt.2018.00002. eCollection 2018.
Excessive Sleepiness and Longer Nighttime in Bed Increase the Risk of Cognitive Decline in Frail Elderly Subjects: The MAPT-Sleep Study. Gabelle A, Gutierrez LA, Jaussent I, Navucet S, Grasselli C, Bennys K, Marelli C, David R, Andrieu S, Berr C, Vellas B, Dauvilliers Y. Front Aging Neurosci. 2017 Sep 28;9:312. doi: 10.3389/fnagi.2017.00312. eCollection 2017.
Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Dufouil C, Dubois B, Vellas B, Pasquier F, Blanc F, Hugon J, Hanon O, Dartigues JF, Harston S, Gabelle A, Ceccaldi M, Beauchet O, Krolak-Salmon P, David R, Rouaud O, Godefroy O, Belin C, Rouch I, Auguste N, Wallon D, Benetos A, Pariente J, Paccalin M, Moreaud O, Hommet C, Sellal F, Boutoleau-Bretonniére C, Jalenques I, Gentric A, Vandel P, Azouani C, Fillon L, Fischer C, Savarieau H, Operto G, Bertin H, Chupin M, Bouteloup V, Habert MO, Mangin JF, Chêne G; MEMENTO cohort Study Group. Alzheimers Res Ther. 2017 Aug 29;9(1):67. doi: 10.1186/s13195-017-0288-0.
Use of Speech Analyses within a Mobile Application for the Assessment of Cognitive Impairment in Elderly People. Konig A, Satt A, Sorin A, Hoory R, Derreumaux A, David R, Robert PH. Curr Alzheimer Res. 2018;15(2):120-129. doi: 10.2174/1567205014666170829111942.
Recommendations for the Use of Serious Games in Neurodegenerative Disorders: 2016 Delphi Panel. Manera V, Ben-Sadoun G, Aalbers T, Agopyan H, Askenazy F, Benoit M, Bensamoun D, Bourgeois J, Bredin J, Bremond F, Crispim-Junior C, David R, De Schutter B, Ettore E, Fairchild J, Foulon P, Gazzaley A, Gros A, Hun S, Knoefel F, Olde Rikkert M, Phan Tran MK, Politis A, Rigaud AS, Sacco G, Serret S, Thümmler S, Welter ML, Robert P. Front Psychol. 2017 Jul 25;8:1243. doi: 10.3389/fpsyg.2017.01243. eCollection 2017.
Antipsychotic prescribing for Alzheimer's disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study. Tifratene K, Manera V, Fabre R, Gros A, Thummler S, Pradier C, Robert P, David R. Alzheimers Res Ther. 2017 Apr 26;9(1):34. doi: 10.1186/s13195-017-0256-8.
Olfactory disturbances in ageing with and without dementia: towards new diagnostic tools. Gros A, Manera V, De March CA, Guevara N, König A, Friedman L, Robert P, Golebiowski J, David R. J Laryngol Otol. 2017 Jul;131(7):572-579. doi: 10.1017/S0022215117000858. Epub 2017 Apr 20.
Objective measurement of gait parameters in healthy and cognitively impaired elderly using the dual-task paradigm. König A, Klaming L, Pijl M, Demeurraux A, David R, Robert P. Aging Clin Exp Res. 2017 Dec;29(6):1181-1189. doi: 10.1007/s40520-016-0703-6. Epub 2017 Jan 27.
Recommendations for the Use of ICT in Elderly Populations with Affective Disorders. Gros A, Bensamoun D, Manera V, Fabre R, Zacconi-Cauvin AM, Thummler S, Benoit M, Robert P, David R. Front Aging Neurosci. 2016 Nov 8;8:269. eCollection 2016.
[Serious game, a link between institution and home]. Robert P, Manera V, Brousse J, Bourgeois J, Foulon P, David R. Soins Gerontol. 2016 Sep-Oct;21(121):24-26. doi: 10.1016/j.sger.2016.07.007. French.
[Neuropsychiatric disorders and technological solutions]. Bensamoun D, Gros A, Manera V, König A, Guérin O, Robert P, David R. Soins Gerontol. 2016 Sep-Oct;21(121):18-20. doi: 10.1016/j.sger.2016.07.005. French.
[Robotics and improvement of the quality of geriatric care]. Ettore É, Wyckaert E, David R, Robert P, Guérin O, Prate F. Soins Gerontol. 2016 Sep-Oct;21(121):15-17. doi: 10.1016/j.sger.2016.07.004. French.
Evolution of the Antidepressant Prescribing in Alzheimer's Disease and Related Disorders Between 2010 and 2014: Results from the French National Database on Alzheimer's Disease (BNA). David R, Manera V, Fabre R, Pradier C, Robert P, Tifratene K. J Alzheimers Dis. 2016 Jul 2;53(4):1365-73. doi: 10.3233/JAD-160238.
A Feasibility Study with Image-Based Rendered Virtual Reality in Patients with Mild Cognitive Impairment and Dementia. Manera V, Chapoulie E, Bourgeois J, Guerchouche R, David R, Ondrej J, Drettakis G, Robert P. PLoS One. 2016 Mar 18;11(3):e0151487. doi: 10.1371/journal.pone.0151487. eCollection 2016.
Characteristics of Alzheimer's Disease Patients with Severe Executive Disorders. Godefroy O, Bakchine S, Verny M, Delabrousse-Mayoux JP, Roussel M, Pere JJ; REFLEX study group:. J Alzheimers Dis. 2016;51(3):815-25. doi: 10.3233/JAD-150971.
Exercise Plus Cognitive Performance Over and Above Exercise Alone in Subjects with Mild Cognitive Impairment. Sacco G, Caillaud C, Ben Sadoun G, Robert P, David R, Brisswalter J. J Alzheimers Dis. 2016;50(1):19-25. doi: 10.3233/JAD-150194.
Associations between Neuropsychiatric Symptoms and Cerebral Amyloid Deposition in Cognitively Impaired Elderly People. Bensamoun D, Guignard R, Furst AJ, Derreumaux A, Manera V, Darcourt J, Benoit M, Robert PH, David R. J Alzheimers Dis. 2016;49(2):387-98. doi: 10.3233/JAD-150181.
[Frequency and coding of psychiatric care of short-stay patients]. Bourdais-Mannone C, Gendreike Y, Clamen A, Teadi J, Jover F, David R, Cherikh F, Staccini P. Sante Publique. 2015 Mar-Apr;27(2):221-31. French.
[Alzheimer's disease and the organization of visits to cultural sites]. Lafont V, Brinck-Jensen S, Filleau C, Greenblat C, David R, Robert P. Soins Gerontol. 2015 Jul-Aug;(114):39-42. doi: 10.1016/j.sger.2015.03.012. French.
The Role of Information and Communication Technologies in Clinical Trials with Patients with Alzheimer's Disease and Related Disorders. König A, Sacco G, Bensadoun G, Bremond F, David R, Verhey F, Aalten P, Robert P, Manera V. Front Aging Neurosci. 2015 Jun 9;7:110. doi: 10.3389/fnagi.2015.00110. eCollection 2015. Review. No abstract available.
Ecological Assessment of Autonomy in Instrumental Activities of Daily Living in Dementia Patients by the Means of an Automatic Video Monitoring System. König A, Crispim-Junior CF, Covella AG, Bremond F, Derreumaux A, Bensadoun G, David R, Verhey F, Aalten P, Robert P. Front Aging Neurosci. 2015 Jun 2;7:98. doi: 10.3389/fnagi.2015.00098. eCollection 2015.
'Kitchen and cooking,' a serious game for mild cognitive impairment and Alzheimer's disease: a pilot study. Manera V, Petit PD, Derreumaux A, Orvieto I, Romagnoli M, Lyttle G, David R, Robert PH. Front Aging Neurosci. 2015 Mar 17;7:24. doi: 10.3389/fnagi.2015.00024. eCollection 2015.
Automatic speech analysis for the assessment of patients with predementia and Alzheimer's disease. König A, Satt A, Sorin A, Hoory R, Toledo-Ronen O, Derreumaux A, Manera V, Verhey F, Aalten P, Robert PH, David R. Alzheimers Dement (Amst). 2015 Mar 29;1(1):112-24. doi: 10.1016/j.dadm.2014.11.012. eCollection 2015 Mar.
Validation of an automatic video monitoring system for the detection of instrumental activities of daily living in dementia patients. König A, Crispim Junior CF, Derreumaux A, Bensadoun G, Petit PD, Bremond F, David R, Verhey F, Aalten P, Robert P. J Alzheimers Dis. 2015;44(2):675-85. doi: 10.3233/JAD-141767.
Actigraphic motor activity in mild cognitive impairment patients carrying out short functional activity tasks: comparison between mild cognitive impairment with and without depressive symptoms. Yakhia M, König A, van der Flier WM, Friedman L, Robert PH, David R. J Alzheimers Dis. 2014;40(4):869-75. doi: 10.3233/JAD-131691.
A review of current information and communication technologies: can they be used to assess apathy? König A, Aalten P, Verhey F, Bensadoun G, Petit PD, Robert P, David R. Int J Geriatr Psychiatry. 2014 Apr;29(4):345-58. doi: 10.1002/gps.4017. Epub 2013 Sep 5. Review.
Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis. Zeitzer JM, David R, Friedman L, Mulin E, Garcia R, Wang J, Yesavage JA, Robert PH, Shannon W. Am J Geriatr Psychiatry. 2013 Apr;21(4):391-7. doi: 10.1016/j.jagp.2012.12.012. Epub 2013 Feb 6.
Detection of activities of daily living impairment in Alzheimer's disease and mild cognitive impairment using information and communication technology. Sacco G, Joumier V, Darmon N, Dechamps A, Derreumaux A, Lee JH, Piano J, Bordone N, Konig A, Teboul B, David R, Guerin O, Bremond F, Robert P. Clin Interv Aging. 2012;7:539-49. doi: 10.2147/CIA.S36297. Epub 2012 Dec 4.